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diarrhea, stomach aches, and digestive distress.

They can range from mild to severe and include ( 2): Symptoms of histamine intolerance often resemble those of an allergic reaction. As a result, histamine levels rise, leading to various physical symptoms. When your DAO levels are too low, it’s difficult for your body to efficiently metabolize and excrete excess histamine. One of the suspected causes of histamine intolerance is DAO deficiency ( 2).

Histamine intolerance is a medical condition that occurs as a result of elevated histamine levels. Summaryĭiamine oxidase (DAO) is an enzyme that helps break down excess histamine in your body, thus easing uncomfortable symptoms, such as nasal congestion, itchy skin, headaches, and sneezing. It naturally occurs in certain foods - especially those that are aged, cured, or fermented like cheese, wine, pickles, and smoked meats ( 1).ĭAO keeps histamine levels in a healthy range to avoid uncomfortable histamine-induced symptoms.

You may also ingest histamine through your diet. If you’ve ever experienced an allergic reaction, you’re probably familiar with common symptoms associated with elevated histamine levels, such as nasal congestion, itchy skin, headaches, and sneezing. Histamine is a naturally occurring compound that helps regulate specific functions of your digestive, nervous, and immune systems. Its primary function is to break down excess histamine in your body ( 1). Diamine oxidase (DAO) is a digestive enzyme produced in your kidneys, thymus, and the intestinal lining of your digestive tract.